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异常的BCAT1表达增加了MTOR活性,加速了慢性淋巴细胞白血病的疾病进展

Qiangqiang Shao1, Jedrzej Wykretowicz1, Nan Hu1

  • 1Departments of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.

Leukemia
|October 25, 2024
PubMed
概括

慢性淋巴细胞白血病 (CLL) 中分支链氨基酸转移酶1 (BCAT1) 的异常表达与生存率低下和Venetoclax敏感性降低有关. 在CLL中,BCAT1可能代表了一个新的治疗点.

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