免疫疗法反应在肝细胞癌中诱导不同的三级淋巴体结构形态
Daniel H Shu1,2,3, Won Jin Ho2,3, Luciane T Kagohara2,3
1Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, USA.
Nature immunology
|October 25, 2024
概括
肝细胞癌中三级淋巴体结构 (TLS) 的高密度预测了免疫治疗的更好反应. 这些结构也可能支持T细胞在瘤消除后的记忆形成.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 三级淋巴体结构 (TLS) 与在用免疫检查点阻塞治疗的固体瘤中更好的结果有关.
- TLS的预后和预测作用以及它们的分辨模式需要进一步研究.
研究的目的:
- 调查TLS在肝细胞癌 (HCC) 治疗新辅助免疫治疗中的预后和预测价值.
- 在瘤回归区域中描述TLS的形态学和细胞组成.
主要方法:
- 在接受新辅助免疫治疗的患者的HCC样本中分析内TLS密度.
- 在瘤回归区域中对TLS形态和免疫细胞透的组织病理学检查.
主要成果:
- 外科手术时的高内TLS密度与HCC中改善的病理反应和无复发的生存率相关.
- 在回归瘤中TLS的卷积显示了分散的B细胞毛囊,但具有成熟树突细胞的持久T细胞区域.
- 在涉及TLS的持续T细胞区域中观察到T细胞记忆标记的增加.
结论:
- 三级淋巴体结构作为HCC免疫治疗反应的预后和预测标记.
- 晚期TLS可能在促进T细胞记忆的瘤后消除中发挥作用,即使在回归的区域.
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