在艾滋病毒感染的老年人中药物过载的流行:MedSafer研究
Émilie Bortolussi-Courval1, Elizabeth Smyth2, Cecilia Costiniuk1,3
1Division of Experimental Medicine, Faculty of Medicine and Health Sciences, McGill University, Montréal, Québec, Canada.
BMC infectious diseases
|October 25, 2024
概括
艾滋病毒感染的老年人经常因多药制药而经历药物过载. 减少潜在不合适的药物 (PIMs) 对于改善健康结果和预防这种人群中不良药物事件至关重要.
科学领域:
- 老年医学 老年医学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 携带艾滋病毒的老年人 (PWH) 容易受到多药性治疗的影响,即使用多种药物.
- 虽然许多药物可以治疗艾滋病毒和并发症,但有些药物可能是不合适的药物 (PIM),增加了危害.
- 由PIMs定义的药物过载在这个人口群体中构成重大风险.
研究的目的:
- 描述老年PWH中多药和药物过载的流行情况.
- 为了确定与这种人群中药物过载相关的因素.
主要方法:
- 在第三级护理艾滋病毒诊所对100名50岁以上的PWH进行了回顾性研究 (2022年6月至2023年6月).
- 使用MedSafer软件分析了药物和实验室值,以确定PIM及其风险.
- 测量了多药 (≥5种药物,有/没有ART) 和药物过载 (≥1种PIM) 的患病率.
主要成果:
- 多药制是普遍存在的:包括ART在内的89%,不包括ART的60%.
- 药物过载影响了58%的患者,其中37.4%的PIM是高风险的.
- 多药是药物过载的唯一确定的预测因素.
结论:
- 老年PWH面临着药物过载和高风险PIMs的重大风险.
- 停止PIM的处方是一种可行的策略,可以提高药物的适当性.
- 减少PIM可以减轻老年PWH药物不良事件的风险.
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