在中年时代,中叶中部子区域的结构和功能性差异
Marie Caillaud1, Isabelle Gallagher2, Janelle Foret3
1University of Texas at Austin, Austin, TX, USA. marie.caillaud@austin.utexas.edu.
BMC neuroscience
|October 25, 2024
概括
与男性相比,中年女性表现出明显的中叶 (MTL) 结构,但大脑连接性仍然相似. 需要进一步研究,以了解这些结构差异是否会影响未来的大脑健康和阿尔茨海默病 (AD) 风险.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 衰老研究研究 衰老研究
背景情况:
- 人们越来越多地认识到老龄化和阿尔茨海默病 (AD) 易感性方面的性别差异.
- 中间叶 (MTL) 形态和中年性别差异的功能连接性是不太了解的.
- 中年期是显著认知衰退的典型年龄之前,这使得它成为调查的关键时期.
研究的目的:
- 系统地分析中年成人中MTL子区域之间的结构和功能连接.
- 研究MTL形态的性别相关差异及其与更广泛的大脑网络功能的潜在联系.
- 为了测试这一假设,MTL子区域的形态性差异表现为功能区别.
主要方法:
- 201名认知正常的成年人 (40-60岁) 被按年龄和性别分层.
- 进行了高分辨率结构性MRI和静止状态功能性MRI (rsfMRI).
- 自动细分划分了MTL次区域;ANOVA评估了形态;CONN工具箱分析了功能连接 (ROI-to-ROI,fALFF).
主要成果:
- 在年轻女性和男性 (p < 0.001) 之间,在后部海马体 (pHPC) 和副海马体皮质 (PHC) 中观察到显著的体积差异.
- 在老年女性和男性之间发现的体积差异较小 (p < 0.05).
- 两组之间没有检测到功能连接模式或fALFF分数的显著差异.
结论:
- 中年成人在后海马体和副海马体皮层中表现出明显的与性别相关的形态差异.
- 尽管有结构上的差异,但在中年时代的MTL中,男性和女性在MTL中具有相似的大脑连接模式.
- 需要进行纵向研究,以确定这些中年形态差异是否会影响未来的功能变化和大脑衰退.
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