用多层次和潜增长模型进行纵向调解分析:一种可分离的效应因果关系方法
Chiara Di Maria1, Vanessa Didelez2
1Department of Economics, Business and Statistics, University of Palermo, Viale delle Scienze, Building 13, Palermo, 90128, Italy.
BMC medical research methodology
|October 25, 2024
概括
本研究介绍了分析复杂医疗模型中介的可分离的因果关系,解决了诸如治疗后混和潜在变量等挑战. 结果显示,模型的错误规范明显偏差了随着时间的推移的影响估计.
科学领域:
- 因果推理的原因推理.
- 生物统计学 生物统计学
- 纵向数据分析的数据分析.
背景情况:
- 因果调解分析在医学研究中很常见,但由于多层次和潜增长模型中的治疗后混和潜在变量,估计自然效应具有挑战性.
- 现有的模型在具有复杂数据结构的纵向设置中难以准确估计介导效应.
研究的目的:
- 用可分离的调解效应,为多层和潜增长模型提出一种新的因果解释.
- 为了克服自然效应的局限性,在存在后处理混和潜在变量时.
主要方法:
- 使用g-公式,对可识别性条件和可分离的调解效应的分析表达式的正式导出.
- 一个模拟研究,以评估模型错误规范和假设违规对影响估计的影响.
- 应用到现实世界的数据.
主要成果:
- 模型的错误规范,特别是严重的病例,显著影响调解效应的估计,随着时间的推移,偏差会增加.
- 在混合效应与潜增长模型中,违反可识别性假设对可分离效应估计的影响不同.
结论:
- 提出的可分离效应为多层次和潜增长模型提供了有效的因果解释.
- 强调谨慎选择模型的关键重要性,因为错误规范对影响估计的重大影响.
相关概念视频
Mechanistic Models: Compartment Models in Individual and Population Analysis
29
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
29
Longitudinal Research
11.9K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.9K
Longitudinal Studies
139
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
139
Comparing the Survival Analysis of Two or More Groups
155
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
155
Two-Way ANOVA
2.6K
The two-way ANOVA is an extension of the one-way ANOVA. It is a statistical test performed on three or more samples categorized by two factors - a row factor and a column factor. Ronald Fischer mentioned it in 1925 in his book 'Statistical Methods for Researchers.'
The two-way ANOVA analysis initially begins by stating the null hypothesis that there is an interaction effect between the two factors of a dataset. This effect can be visualized using line segments formed by joining the...
The two-way ANOVA analysis initially begins by stating the null hypothesis that there is an interaction effect between the two factors of a dataset. This effect can be visualized using line segments formed by joining the...
2.6K
Factorial Design
13.0K
Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
13.0K


