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切除侵袭性粘膜性肺腺癌的预后因素:系统性审查和元分析

Fangfang Shen¹, Xinyu Wu², Jiang Geng¹

¹Department of Respiratory Medicine, Shanxi Cancer Institute, Shanxi Cancer Hospital, Cancer Hospital of Chinese Academy of Medical Sciences Shanxi Hospital, Shanxi Medical University Affiliated Hospital, Taiyuan, 030000, China.

|October 25, 2024

概括

确定了手术后切除侵袭性粘膜性肺腺癌 (IMA) 的预后因素. 男性性别,吸烟,晚期,差异化,内脏膜入侵 (VPI),通过空气空间传播 (STAS) 和KRAS突变对生存产生负面影响.

科学领域:

肺部医学肺部医学
手术瘤学手术瘤学
基因组医学是基因组医学.

背景情况:

手术是早期侵袭性粘膜性肺腺癌 (IMA) 的首要治疗方法.
识别预后因素对于优化切除IMA的治疗策略至关重要.
为了评估这些因素,进行了系统审查和元分析.

研究的目的:

系统地审查和分析切除侵袭性粘膜性肺腺癌患者的预后因素.
确定总生存 (OS) 和无疾病生存/无复发生存 (DFS/RFS) 的临床病理和基因组预测因素.

主要方法:

在PubMed,Embase和Cochrane图书馆的系统文献搜索 (2015年1月至2024年1月).
包括16项研究,包括3,484名切除IMA的患者.
使用危险比率 (HR) 和95%置信区间 (CI) 来评估预后影响的元分析.

主要成果:

男性性别和吸烟与更差的预后有关.
晚期临床阶段,差异化不良,内脏膜入侵 (VPI) 和通过空气空间传播 (STAS) 与更糟糕的结果相关.
存在KRAS突变也被确定为负面预后因素.

结论:

切除IMA的关键预后因素包括性别,吸烟状态,临床阶段,瘤分化,VPI,STAS和KRAS突变.
这些因素显著影响DFS/RFS和OS.
了解这些预测因素可以促进IMA患者的个性化治疗计划.

关键词:

侵袭性粘膜腺癌的癌症.肺癌是一种肺癌.进行元分析分析.预测预后预后

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