内脏脂质积累指标与胆结石之间的关联:基于NHANES 2017-2020年的横截面研究
Weigen Wu1,2, Yuchen Pei1,2, Junlong Wang1,2
1Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan Er Road, Guangzhou, Guangdong Province, 510080, P.R. China.
Lipids in health and disease
|October 26, 2024
概括
腰围等内脏脂肪指标的增加与更高的胆结石风险有关. 一个新的诺莫格拉姆模型显示了成年人早期胆结石检测的前景.
科学领域:
- 代谢健康和疾病流行病学.
- 诊断标记的开发. 诊断标记的开发.
背景情况:
- 肥胖是胆结石形成的重要危险因素.
- 早期识别胆结石风险因素可以改善患者的治疗结果.
研究的目的:
- 调查内脏脂质积累指标与胆结石发生之间的关联.
- 开发和验证胆结石存在的预测模型.
主要方法:
- 对3224名成年人的横截面研究.
- 对内脏脂肪 (METS-VF),腰围 (WC),脂质积累产物 (LAP) 和内脏脂肪指数 (VAI) 的代谢评分的分析.
- 使用多变量逻辑回归,光滑曲线拟合,LASSO回归和名ogram构造.
主要成果:
- 内脏脂质指标 (METS-VF,WC,LAP,VAI) 与胆结石患病率有显著的相关性.
- 对于每个指标,确定了值效应.
- 一个诺莫格拉姆模型显示出用于胆结石检测的良好的区分能力 (AUC = 0.725).
结论:
- 较高的内脏脂肪标志物与增加胆结石患病率有关.
- 开发的诺莫格拉姆模型显示了识别胆结石风险较高的个体的潜力.
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