对多环芳的职业暴露对精子质量的一年影响
Mª Victoria Peña-García1, Mª José Moyano-Gallego1, Sara Gómez-Melero2
1Clinical Analyses Service, Reina Sofía University Hospital, 14004 Córdoba, Spain.
Antioxidants (Basel, Switzerland)
|October 26, 2024
概括
在太阳能发电厂中暴露于多环芳 (PAHs) 并没有影响精子数量或质量. 然而,PAH暴露与抗氧化能力降低和精液白细胞增加有关.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 职业医学 职业医学 职业医学
背景情况:
- 多环芳 (PAH) 是已知有毒作用的环境污染物,包括致癌性,神经毒性和内分泌干扰.
- 在可能接触有害物质的职业环境中,男性生殖健康是一个关键问题.
研究的目的:
- 调查职业接触PAH对太阳能热发电厂男性工人的生殖健康的影响.
- 评估暴露和未暴露个体的精液质量的细胞和生化标志物.
主要方法:
- 一项涉及61名男性的病例控制研究:32人在太阳能热发电厂暴露于PAHs,29名未暴露的对照.
- 精液质量评估包括精子数量,运动性,活力,形态,DNA碎片化和精液等离子体氧化应激标志物.
- 还评估了白细胞透到精液等离子体中的情况.
主要成果:
- 与对照组相比,暴露在PAHs中的工人表现出明显更高的精液白细胞透率.
- 在暴露的工人的精液等离子体中观察到超氧化物脱酶 (SOD) 的活性降低和较低的谷氨/氧化谷氨 (GSH/GSSG) 比率.
- 在这两组中,氧化应激参数和精子细胞性之间没有发现显著的关系.
结论:
- 在太阳能热发电厂中一年的职业接触PAHs并没有对精子细胞性 (数量,运动性,活力,形态,DNA碎片化) 产生负面影响.
- 暴露于PAH与精液等离子体中抗氧化能力的降低有关.
- 精液等离子体中白细胞透率的增加是与这一队列中PAH暴露相关的关键发现.
相关概念视频
Spermatogenesis
102.2K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.2K
Infertility in Males
253
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
253
Types of Toxins
1.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.6K
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K
Oogenesis
63.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.5K


