乳酸菌会吃掉粉样蛋白质斑块,并在后生物学上减轻因重复扩张障碍和阿尔茨海默病而导致的衰老
1Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Antioxidants (Basel, Switzerland)
|October 26, 2024
概括
益生菌乳酸菌通过向肠道失调和粉样蛋白沉积物来预防阿尔茨海默病 (AD). 它恢复表观遗传调节并增加有益的H2S生产,为ADRD提供了一种新的治疗途径.
科学领域:
- 神经科学和微生物学
- 表观遗传学和肠-大脑轴研究
背景情况:
- 阿尔茨海默病和相关痴呆症 (ADRD) 的特点是粉样蛋白沉积和脑粉样蛋白血管病变 (CAA).
- 以前针对氧化应激,炎症和超脂血症的治疗方法表现出有限的成功.
- 慢性高脂肪饮食 (HFD) 和肠道失调症通过破坏表观遗传调节 (DNMT1,TET2/FTO) 和叶酸1-碳代谢 (FOCM) 循环,促进ADRD.
研究的目的:
- 研究肠-大脑微生物群轴作为ADRD的治疗点.
- 探索Lactobacillus益生菌在抑制氨基酸沉积和增强线粒体转硫和H2S生产方面的潜力.
主要方法:
- 在AD小鼠的皮质中观察到DNMT1和FTO水平的变化.
- 给小鼠服用 Lactobacillus 益生菌产生后生物叶酸和体.
- 评估了与FOCM相关的肠道失调和粉样蛋白沉积物的预防.
主要成果:
- 乳杆菌益生菌预防了肠道失调和粉样蛋白沉积.
- 益生菌产生后生物叶酸和乳酸体,这对ADRD有益.
- 在AD小鼠皮层中观察到DNMT1的水平增加和FTO的降低,这表明表观遗传失调.
结论:
- 乳杆菌益生菌通过调节肠-大脑轴,为ADRD提供了一个有希望的治疗策略.
- 益生菌恢复表观遗传平衡,并通过H2S生产增强线粒体功能.
- 用特定的益生菌向肠道失生症可能会抑制β-粉样蛋白沉积并改善ADRD中的生物能量.
相关概念视频
Amyloid Fibrils
9.3K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.3K
Alzheimer's Disease: Overview
449
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
449
Alzheimer's Disease: Treatment
165
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
165
Lysosomal Hydrolases
3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K


