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在牙周炎中,植物治疗药物对NRF2/KEAP1信号的调节

Giovanni Tossetta¹, Sonia Fantone², Lucrezia Togni³

¹Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy.

Antioxidants (Basel, Switzerland)

|October 26, 2024

概括

牙周炎涉及慢性炎症和骨质损失. 用天然或合成化合物调节NRF2/KEAP1通路可能为这种常见的牙疾病提供新的治疗方法.

科学领域:

牙周病学牙周病学
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

牙周炎是一种常见的炎症性牙疾病,导致牙周损伤和骨再吸收.
核因子红色素2相关因子2 (NRF2) /凯尔奇样ECH相关蛋白1 (KEAP1) 途径对于调节红氧平衡和周期性质炎症至关重要.
NRF2表达减少,而氧化应激在牙周炎中升高,加剧炎症和骨质损失.

研究的目的:

审查关于天然和合成化合物在牙周炎中向NRF2/KEAP1通路的文献.
评估这些化合物的潜力,作为治疗牙周炎的新疗法.
了解这些化合物如何调节牙周组织中的氧化还原平衡和炎症.

主要方法:

在体外和体内研究的系统审查.
对调节NRF2/KEAP1信号通路的化合物的分析.
对氧化应激,炎症和骨再吸收标记物的影响的研究.

主要成果:

几种天然和合成化合物表明能够激活NRF2/KEAP1通路.
在牙周模型中,化合物显示出降低氧化应激和炎症的潜力.
有证据表明,这些调节剂可以减轻与牙周炎相关的膜骨再吸收.

结论:

调节NRF2/KEAP1通路是一种有前途的牙周炎治疗策略.
天然和合成化合物为开发新的治疗方法提供了潜力,以改善牙周炎的结果.
通过NRF2/KEAP1激活来准氧化还原平衡和炎症可能是治疗牙周炎的关键.

关键词:

化合物化合物化合物化合物核因子红色素2相关因子2 (NRF2)氧化应激是一种氧化应激.牙周炎是指牙周炎的一种疾病.植物治疗药物植物治疗药物

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