口腔微生物组和CPT1A在口腔癌脂肪酸代谢中的功能
Zeba Praveen1, Sung-Weon Choi2, Jong Ho Lee2
1Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, Republic of Korea.
International journal of molecular sciences
|October 26, 2024
概括
口腔癌与口腔中的特定细菌有关. 口腔微生物组的变化,包括较高的Streptococcus和Parvimonas,与较差的生存率和改变的酶水平相关,这表明潜在的诊断标记.
科学领域:
- 微生物组研究的研究.
- 口腔瘤学 在口腔瘤学
- 代谢学 代谢学 代谢学
背景情况:
- 口腔微生物组在健康中起着至关重要的作用,其失生症与口腔癌 (OC) 有关.
- 口腔细菌和OC机制之间的确切关系需要进一步阐明.
研究的目的:
- 研究口腔微生物组与口腔癌中的分子机制之间的关联.
- 确定潜在的微生物生物标志物用于口腔癌诊断和预后.
主要方法:
- 使用16S rRNA测序对1022个唾液样本 (157名OC患者,865名对照) 的分析.
- 应用光渐变增强机 (LightGBM) 模型来识别关键细菌种类.
- 测量酶水平,细胞因子和短链脂肪酸 (SCFA).
主要成果:
- 四个细菌系 (Streptococcus,Parvimonas,Corynebacterium,Prevotella) 与OC有显著的关联.
- 在OC患者中,Streptococcus和Parvimonas的含量较高,Corynebacterium和Prevotella的含量较低,脂肪酸氧化酶 (例如,CPT1A) 的含量较高.
- 健康对照组的SCFA和CD4+T辅助细胞数量较高;较高的Streptococcus/Parvimonas与较差的生存率相关 (DFS/OS).
结论:
- 特定口腔细菌系的变化与口腔癌中细胞因子,CPT1A水平和SCFA的变化有关.
- 这些微生物组和代谢变化可能成为口腔癌的预测标志物.
- 这项研究强调了口腔微生物组作为口腔癌的诊断和预后工具的潜力.
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