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与多发性硬化症相关的选择性介质蛋白:新的方向,潜在的目标和治疗前景

Hubert Mado¹, Artur Stasiniewicz¹, Monika Adamczyk-Sowa¹

¹Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, Poland.

International journal of molecular sciences

|October 26, 2024

概括

互白蛋白显著影响多发性硬化症 (MS) 的发展和进展. 某些互白蛋白提供神经保护并促进复髓化,这表明MS的潜在治疗点.

科学领域:

神经免疫学神经免疫学
中枢神经系统疾病中枢神经系统疾病
炎症性疾病炎症性疾病

背景情况:

多发性硬化症 (MS) 是一种慢性中枢神经系统炎症性疾病,其特征是脱髓化和神经退行.
互白蛋白在多发性硬化症的发病过程中起着至关重要的作用,但它们的确切影响需要进一步阐明.
了解互白素的功能对于开发新型多发性硬化疗法至关重要.

研究的目的:

审查和综合当前关于白细胞间蛋白对MS发展和进展的影响的研究.
评估在MS中准特定的互白蛋白的治疗潜力.
为未来的多发性硬化研究和生物标志物开发确定有前途的互白蛋白.

主要方法:

在PubMed上进行了全面的文献搜索,使用与互白蛋白和MS相关的关键词.
搜索仅限于2014年至2024年间发表的文章.
总共有12,731篇文章被确定,其中100篇被选择进行深入审查.

主要成果:

产生互白素-10 (IL-10) 的细胞表现出神经保护作用,而IL-6的合成与恶化的神经炎症有关.
支持炎症的细胞因子包括IL-12,IL-23和IL-18.
用抗IL-12p40单克隆抗体治疗在MS患者中表现出有益作用.
IL-4和IL-13作为抗炎细胞因子,促进复髓化并抑制MS的进展.

结论:

特定的互白蛋白,如IL-4和IL-13,具有与MS相关的抗炎和神经保护性质.
准IL-12p40已经在MS中显示出治疗前景.
互白蛋白代表了未来多发性硬化症研究的重要领域,可能导致新的治疗方法和预后标记物.

关键词:

它们是 ILs ILs ILs.在MSMSMSMSMSMSMSMSMSMS中,我们可以看到细胞因子细胞因子它们包括interleukins和interleukins.微质细胞中的微质细胞多发性硬化症多发性硬化症神经炎症是一种神经炎症.神经保护神经保护

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