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免疫检查点抑制剂疗法和与克隆性血液形成的关联

Abhay Singh1, Nuria Mencia Trinchant2, Rahul Mishra3

  • 1Leukemia and Myeloid Disorders Program, Cleveland Clinic, Cleveland, OH 44106, USA.

International journal of molecular sciences
|October 26, 2024
PubMed
概括

免疫检查点阻塞 (ICB) 疗法可能会驱动黑色素瘤和NSCLC患者的克隆血液形成 (CH) 扩张,特别是影响DNMT3A和TET2突变. 这表明CH可能是ICB反应的生物标志物,并表明未来的白血病风险.

关键词:
在DNMT3A中,它是DNMT3A.在TET2的基础上.不确定的潜在的克隆性血液形成.免疫检查点封锁封锁免疫检查点抑制剂免疫检查点抑制剂黑色素瘤是一种黑色素瘤.非小细胞肺癌的肺癌.

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