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树枝状多糖化合物通过抑制p53/mTOR通路来缓解MCD饮食诱导的NASH

Dajin Pi¹, Zheng Liang¹, Maoxing Pan¹

¹School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.

International journal of molecular sciences

|October 26, 2024

概括

来自Atractylodes lancea根茎 (AP) 的新型多糖体在预防非酒精性脂肪肝炎 (NASH) 方面表现有前途. 在小鼠模型中,AP有效降低了肝炎和脂质积累,这表明了潜在的新治疗途径.

科学领域:

肝病学肝病学是一种肝病学.
药理学药理学是指药理学的学科.
自然产品化学自然产品化学

背景情况:

非酒精性脂肪肝炎 (NASH) 是一种进展性肝病,没有经批准的治疗方法.
NASH的特点是肝脏炎症,脂肪积累和潜在的纤维化.
目前对NASH的治疗选择有限.

研究的目的:

为了研究来自Atractylodes lancea根茎 (AP) 的多糖在NASH上的预防作用.
阐明AP在NASH中的作用的基本机制.
评估AP作为NASH的潜在天然治疗剂.

主要方法:

从Atractylodes lancea rhizome中分离出一个多糖 (AP).
建立一种甲素和胆缺乏症 (MCD) 饮食诱导的NASH小鼠模型.
评估AP对肝脏肥胖症,炎症,自和铁症的影响.

主要成果:

在NASH小鼠中,AP显著降低了肝脂积累.
AP在肝脏中表现出抗炎作用.
在肝细胞中,AP调节了自和铁的途径,防止了NASH的发展.

结论:

阿特拉提洛德斯兰西亚多糖 (AP) 显示出对NASH的预防作用.
AP的机制包括减少脂质积累,炎症和调节细胞应激通路.
AP代表了一种有前途的天然化合物,用于NASH治疗的进一步研究.

关键词:

阿特拉提洛德斯是兰西亚根茎的多糖体.非酒精性型肝炎的疾病.在p53/mTOR中,p53/mTOR是

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