组织和器官冷保存在生物银行中的现状和挑战
Irina V Khaydukova1, Valeria M Ivannikova1, Dmitry A Zhidkov1
1Department of Refrigeration and Cryogenic Technology, Conditioning Systems, and Life Support Systems, Bauman Moscow State Technical University, 105005 Moscow, Russia.
International journal of molecular sciences
|October 26, 2024
概括
冷保存的进步使组织和细胞的成功保存成为可能,改善生殖和再生医学. 冰晶形成和复杂组织的保存等挑战需要进一步的研究,以获得更广泛的生物医学应用.
科学领域:
- 生物医学科学 生物医学科学
- 细胞生物学 细胞生物学
- 低温生物学 低温生物学
背景情况:
- 组织和细胞的冷保存技术取得了重大进展.
- 尽管取得了进展,但在实现最佳保护结果方面仍然存在挑战.
研究的目的:
- 审查冷保存的现状,包括方法,成就和挑战.
- 探索该领域的未来研究方向.
主要方法:
- 审查当代冷保存技术,包括缓慢冷和玻璃化.
- 分析冷保护剂的作用和冷却/变暖速度.
主要成果:
- 已经成功地冷保存了胚胎和卵巢组织,进步了生殖医学.
- 已注意到冷保存样本的融后生存和功能得到改善.
结论:
- 冷保存对生物医学具有变革性的潜力,特别是在再生疗法中.
- 需要进一步的创新来克服诸如冰晶形成和复杂组织和器官的保存等挑战.
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