中性细胞外细胞陷在儿科炎性肠病中:在性结肠炎中的潜在作用
Rachel Shukrun1,2,3, Victoria Fidel1, Szilvia Baron1
1Pediatric Hemato-Oncology Research Laboratory, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
中性细胞外细胞陷 (NETs) 在儿科炎性肠病 (IBD) 活检和血液中升高,特别是在性结肠炎 (UC) 中. 在UC患者中实现缓解的NET形成正常化,表明潜在的治疗点.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),是一种慢性肠道炎症,影响儿童和成人.
- 中性粒细胞外细胞陷 (NETs) 是中性粒细胞衍生的结构,在各种炎症条件下涉及组织损伤.
研究的目的:
- 研究NET在儿科IBD中的存在和作用.
- 为了比较小儿IBD患者的肠道活检和周围血液中的NET水平与健康对照.
主要方法:
- 对20名儿科IBD患者 (CD和UC) 和对照患者的肠道活检和周围血液的分析.
- 评估中性粒细胞透和NET形成使用活检染色和中性粒细胞激活试验.
- 测量NET蛋白酶活性和评估在缓解期间UC患者的NET形成.
主要成果:
- 儿科IBD活检 (UC和CD) 显示中性粒细胞和NET水平明显高于对照组.
- 性结肠炎 (UC) 显示出与NETs增加的最强相关性.
- 与对照组和CD患者相比,新诊断的UC患者的外周血液中性粒细胞呈现出较高的NET形成.
- 在成功的缓解诱导治疗后,UC患者的NET形成恢复到正常水平.
结论:
- NETs可能在儿科IBD,特别是UC的发病过程中发挥重要作用.
- 需要进一步的研究来阐明儿科IBD中的NET机制.
- 准NET形成可能是儿科IBD的新治疗策略.
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