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Updated: Jun 9, 2025

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
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Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

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与成年老鼠胰腺相比,新生儿中的α-β细胞转分化是为了应对使用链毒素的β细胞适度减少的反应

Jiwon Hahm1,2, Bavina Thirunavukarasu1,2, Reva Gadoo2,3

  • 1Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 3K7, Canada.

International journal of molecular sciences
|October 26, 2024
PubMed
概括

在成年小鼠中,α-β细胞转基因差异化有助于胰腺β细胞在中度耗尽后的质量恢复. 这一涉及双激素细胞的过程有助于部分β细胞的再生,特别是在成年人中.

关键词:
阿尔法细胞的阿尔法细胞细胞.贝塔细胞-贝塔细胞.这是一种双激素的双激素.糖尿病 糖尿病患者 糖尿病患者这里是鼠标鼠标鼠标鼠标鼠标鼠标.胰腺 胰腺是什么这种药物是链条毒素 (streptozotocin).通过转差异化转化.

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Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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