在患有系统性和皮肤性红斑狼的患者中感染E型肝炎病毒
Fulvia Ceccarelli1, Maria Dorrucci2, Carmelo Pirone1
1Lupus Clinic, Rheumatology, Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, 00185 Rome, Italy.
International journal of molecular sciences
|October 26, 2024
概括
肝炎E病毒 (HEV) 感染在皮肤性红斑狼 (CLE) 患者中比系统性红斑狼 (SLE) 患者更常见. 这表明HEV和狼之间存在潜在的联系,特别是CLE.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- 系统性红斑狼 (SLE) 和皮肤性红斑狼 (CLE) 是自身免疫性疾病,具有复杂的遗传和环境原因.
- 乙型肝炎病毒 (HEV) 患病率在地理位置上有所不同,意大利的研究显示出显著的区域差异.
- 了解共感染及其对自身免疫性疾病的影响对于患者管理至关重要.
研究的目的:
- 在被诊断为全身性红斑狼群 (SLE) 和皮肤性红斑狼群 (CLE) 的患者中确定乙型肝炎病毒 (HEV) 的血清流行率.
- 调查HEV感染和特定的红斑狼亚型之间的潜在关联.
- 探索可能的风险因素和病原遗传机制,将HEV与CLE和SLE联系起来.
主要方法:
- 分析了138名患者 (92名SLE,46名CLE) 的血清样本,这些患者参加了狼诊所.
- 使用商业ELISA套件检测抗HEV免疫球蛋白G (IgG) 和M (IgM) 抗体.
- 统计分析以比较SLE和CLE群体之间的HEV患病率,并评估风险因素.
主要成果:
- 与SLE组 (7.6%) 相比,CLE组 (23.9%) 的HEV血清发病率明显高于SLE组 (7.6%).
- 在CLE患者中,抗HEV阳性结果更频繁.
- 虽然没有确定确定的风险因素,但在与动物接触或食用生海鲜的CLE患者中,发现HEV阳性的几率增加.
结论:
- 与SLE患者相比,CLE患者的HEV感染患病率较高.
- 潜在的机制,包括与皮肤抗原或遗传倾向相关的分子模拟,可能解释CLE中HEV易感性增加.
- 需要进一步的研究来阐明HEV和狼病原体之间的相互作用,特别是在CLE.
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