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二次登革热感染导致IL-6和IL-10水平提前升高

Sonia L Espindola¹, Jessica Fay¹, Graciela M Carballo²

¹Laboratorio GIGA, Instituto de Biología Subtropical (IBS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Exactas Químicas y Naturales, Universidad Nacional de Misiones (UNaM), Posadas 3300, Argentina.

International journal of molecular sciences

|October 26, 2024

概括

与初级感染相比,二次登革热病毒 (DENV) 感染在发烧阶段显示出互白素-6 (IL-6) 和互白素-10 (IL-10) 的较早增加. 这些细胞因子水平与低血小板计数等临床症状相关.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

登革热病毒 (DENV) 感染呈现出各种不同的临床表现.
细胞因子概况,包括INTERLEUKIN-6 (IL-6) 和INTERLEUKIN-10 (IL-10),在DENV病变发生过程中至关重要.
在发烧阶段了解细胞因子动力学对于预测疾病严重程度至关重要.

研究的目的:

研究DENV感染发烧期IL-6和IL-10水平的动态变化.
为了比较初级和二级DENV感染之间的细胞因子动力学.
探索细胞因子水平和临床参数之间的相关性.

主要方法:

在病毒性登革热患者中分析IL-6和IL-10水平.
根据抗DENV IgM,将患者分为I期 (早期发烧) 和II期 (晚期发烧) 的分类.
在初级和二次感染中比较细胞因子概况,并与临床数据 (血小板,AST,住院) 相关联.

主要成果:

与初级感染相比,二次DENV感染 (38.2%的病例) 显示IL-6和IL-10的提升较早.
升高的IL-6和IL-10水平与血小板缺血和升高的AST相关,特别是在II期和二次感染中.
细胞因子水平与临床表现和住院风险有关.

结论:

在初级和二级DENV感染中,IL-6和IL-10动态显著不同.
在二次感染中早期的细胞因子升高表明免疫记忆的作用.
细胞因子动态为DENV病原和临床结果提供了洞察力,需要在更广泛的小组中进行进一步的研究.

关键词:

细胞因子细胞因子登革热病毒感染者发烧阶段的发烧阶段感染的各个阶段.二次性感染的第二次感染.

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