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在实验室动物中慢性皮质类固醇管理诱导的情绪障碍:特征,机制和研究前景

Hao Wang¹, Xingxing Wang¹, Huan Wang¹

¹School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

International journal of molecular sciences

|October 26, 2024

概括

在动物模型中,慢性皮质 (CORT) 给药会破坏下丘脑-垂体-上腺 (HPA) 轴,影响情绪和认知功能. 本综述详细介绍了CORT诱导的行为变化和神经生物学机制,强调了矿物质皮质体受体 (MR) /葡萄皮质体受体 (GR) 平衡的重要性.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
精神病学是一个精神病学.

背景情况:

情绪障碍显著影响日常生活,导致残疾和增加自杀风险.
由葡萄糖皮质体 (GCs) 调节的下丘脑-垂体-上腺 (HPA) 轴在神经精神疾病中至关重要.
矿物质皮质体受体 (MR) 和葡萄糖皮质体受体 (GR) 水平的不平衡会破坏神经内分泌的平衡.

研究的目的:

审查慢性皮质 (CORT) 管理诱导的动物模型中的行为和机制变化.
探索神经炎症,热,氧化应激,神经可塑性和死在CORT诱导的功能障碍中的作用.
通过MR/GR比率的破坏来检查CORT对中枢神经系统 (CNS) 的剂量依赖性影响.

主要方法:

总结了在动物模型中使用慢性CORT给药的研究结果.
分析与CORT暴露相关的行为变化研究.
审查CORT对中枢神经系统的影响背后的分子和细胞机制.

主要成果:

慢性CORT的使用会导致与情绪和认知障碍相关的显著行为变化.
关键的机制包括神经炎症,热,氧化应激,改变的神经可塑性和亡.
CORT破坏了MR/GR平衡,导致对中枢神经系统功能产生剂量依赖的影响.

结论:

慢性CORT的使用为研究情绪和认知障碍提供了稳定和可复制的模型.
了解这些机制对于开发针对HPA轴功能障碍的向治疗至关重要.
建议进一步研究这些模型中的认知功能.

关键词:

认知功能认知功能葡萄糖皮质类药物葡萄糖皮质类受体受体下丘脑垂体上腺轴矿物质皮质类受体受体

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