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与心力衰竭和冠状动脉疾病相关的肠道微生物群和代谢变化
Adel A Yafarova1, Elena V Dementeva2, Olga A Zlobovskaya2
1National Medical Research Center for Therapy and Preventive Medicine, Petroverigskyj Lane 10, Bld. 3, 101990 Moscow, Russia.
International journal of molecular sciences
|October 26, 2024
概括
肠道微生物群的变化,包括较高的Bacillota/Bacteroidota比率,与冠状动脉疾病和心力衰竭等心血管疾病有关. 这些变化影响微生物多样性,并使用先进的网络和机器学习分析来识别.
科学领域:
- 微生物组研究的研究.
- 心血管疾病的研究研究.
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群在宿主健康和疾病中起着至关重要的作用.
- 肠道微生物组成的改变越来越多地与心血管疾病 (CVD) 相关.
- 特定的微生物代谢物可能会影响动脉样硬化和心力衰竭的发展.
研究的目的:
- 调查肠道微生物组成和冠状动脉疾病 (CAD) 和心力衰竭减少射出分数 (HFrEF) 的患者的益动脉代谢物之间的关联.
- 通过使用先进的分析技术,识别与CAD和HFrEF相关的关键微生物特征及其相互作用.
- 在心血管疾病患者和健康对照者之间比较肠道微生物群概况和代谢物水平.
主要方法:
- 189名参与者的横截面研究 (93名CAD,43名HFrEF,53名对照).
- 通过下一代测序 (NGS) 和定量聚合酶链反应 (qPCR) 分析肠道微生物群.
- 网络分析,机器学习和统计方法 (包括多样性分析) 用于识别微生物特征和代谢物相关性.
主要成果:
- 观察到肠道微生物群组成的显著差异,在CAD和HFrEF组中Bacillota/Bacteroidota比率较高 (p < 0.001).
- 在疾病组中 (p < 0.001) 发现了降低的α-多样性 (Pielou,Chao1,Faith) 和明显的β-多样性 (p < 0.001).
- 与对照组相比,在CAD和HFrEF患者中发现了较低的三甲基胺N氧化物 (TMAO) 水平 (p < 0.05).
结论:
- 在CAD和HFrEF患者中,肠道微生物群的组成发生了显著的变化.
- 特定的微生物转移和改变的代谢物概况与心血管疾病有关.
- 网络和机器学习分析揭示了与心血管疾病发病有关的复杂肠道微生物相互作用.
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