老年癌症患者的精密瘤学:一个单一中心的经验
Meret Petitat-Berli1,2, Marie Knufinke1,3, Michèle Voegeli1
1Center of Oncology and Hematology, Medical University Clinic Baselland, 4410 Liestal, Switzerland.
International journal of molecular sciences
|October 26, 2024
概括
下一代测序 (NGS) 在癌症治疗中显示出希望,但其在老年人中的实用性仍然不清楚. 这项研究发现,虽然很少有患者从NGS导向治疗中受益,但具有可向突变的老年患者接受的频率较低.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 老年医学 老年医学
背景情况:
- 下一代测序 (NGS) 已经彻底改变了癌症的诊断和治疗.
- 在老年癌症患者中NGS的作用和有效性尚未得到充分证实.
研究的目的:
- 评估NGS在老年癌症患者中的实用性.
- 为了比较接受NGS测试的年轻和老年癌症患者队列之间的治疗结果.
主要方法:
- 在2020年接受NGS的100名癌症患者 (任何亚型/阶段) 的回顾性分析.
- 患者被分为两个队列:<70年 (A) 和≥70年 (B).
- 人口,临床病理和生存数据的比较 (无进展生存率 (PFS) 和整体生存率 (OS)).
主要成果:
- 27%的患者有可向突变.
- 8%的人接受了NGS决定的向治疗,老年患者的发病率较低 (19%与A队列中的45%相比,p=0.2).
- 3%的患者受益于向治疗 (PFS>6个月);没有观察到年龄分层的显著差异 (p=0.08).
结论:
- NGS在诊断或治疗方法中没有显著的年龄分层差异.
- 很少有患者从NGS指导治疗中受益.
- 具有可向突变的老年癌症患者不太可能接受向治疗.
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328


