儿科急性淋巴细胞白血病治疗对心脏再极化的影响
Diana R Lazar1,2, Simona Cainap2,3, Florin Leontin Lazar4
1Department No. 11, Oncology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
接受化疗的儿童癌症患者表现出早期的,无声的心脏再极化变化. 监测心电图 (ECG) 参数可以帮助在治疗期间识别心脏风险.
科学领域:
- 心脏病学 心脏病学
- 儿科瘤学 儿科瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿童癌症幸存者面临心脏功能障碍的风险增加.
- 早期识别有风险的患者对于管理长期健康至关重要.
- 像多克索鲁比辛和环胺这样的抗癌药物可能会带来心脏毒性风险.
研究的目的:
- 在小儿急性淋巴细胞白血病 (ALL) 患者的多克索鲁比 (DOX) 和环胺 (CPM) 化疗期间调查24小时霍尔特心电图 (ECG) 复极变化.
- 为了识别心脏毒性的早期指标.
- 评估化疗对心脏再极化参数的影响.
主要方法:
- 这是一项前性观察性研究,涉及37名儿科ALL患者.
- 治疗第8,29和36天的基线心电图和连续24小时的霍尔特心电图.
- 评估QT间隔,纠正的QT间隔 (QTc),QTc分散和ST段变化.
主要成果:
- 超过三分之一的患者在基线时有异常的静止心率.
- 在化疗期间观察到心率和QTc分散的统计显著增加,特别是在第一个DOX剂量后.
- 从第8天到第36天,ST段抑郁的发病率增加.
结论:
- 在儿科ALL患者的化疗期间,发生早期的,静默的复极化变化.
- 这些发现可能会增强对心脏毒性机制的理解.
- 有可能改善儿科癌症患者的心脏风险分层,等待在更大的研究中验证.
更多相关视频
10:49Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
08:03Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
Published on: October 20, 2022
相关概念视频
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Electrophysiology of Normal Cardiac Rhythm
Myocarditis III: Medical Management
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Cardiopulmonary Resuscitation IV: Pharmacological Management
