用抗发作药物补充的儿童的维生素D补充剂:随机对照试验
Fahad A Bashiri1,2, Abrar Hudairi1,2, Muddathir H Hamad1,2
1Department of Pediatrics, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
Children (Basel, Switzerland)
|October 26, 2024
概括
每天服用1000 IU维生素D (胆胺) 比400 IU更有效地维持儿童的维生素D水平. 这种较高的剂量也可以改善单一治疗儿童的控制.
科学领域:
- 儿科神经学 儿科神经学
- 内分泌学 在内分泌学.
- 临床药理学 临床药理学
背景情况:
- 抗发作药物 (ASM) 对于儿童管理至关重要,但可以损害维生素D的新陈代谢,导致缺乏.
- 由于ASM使用,维生素D缺乏是儿童的公认问题.
- 这项研究调查了这种脆弱的儿科患者群体中最佳的维生素D补充水平.
研究的目的:
- 为了评估每日400 IU与1000 IU胆酸盐剂量在维持儿童维生素D水平的有效性.
- 评估维生素D补充剂对控制的影响,特别是在单一治疗的儿童中.
主要方法:
- 一个IV期随机对照试验,涉及2至16岁的患有的儿童在ASM上.
- 参与者被分为单疗法和多疗法组,并随机分配给每天400 IU或每天1000 IU胆醇.
- 评估包括25-基维生素D (25(OH) D) 水平,人体测量和发作控制在基线和6个月.
主要成果:
- 在6个月后,与400 IU/day组 (75.0%) 相比,每天1000 IU/day维生素D组的儿童中,25 ......OH) D水平低于75 nmol/L (54.8%) 的比例较低.
- 在单一治疗小组中,维生素D治疗与无儿童的增加相关,从69%增加到83.6%.
结论:
- 每天1000 IU的维生素D (胆) 剂量似乎更有效地维持儿童维生素D的充足量.
- 补充1000 IU/天可能为控制提供额外的好处,特别是在单一治疗的儿童中.
- 这些发现支持为患有的儿童提供更高剂量的维生素D补充剂,以解决缺陷并可能提高治疗结果.
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