发展中国家儿童缺铁性贫血和发育迟缓之间的关系:系统性审查和元分析
Caroline Oktarina1, Charisma Dilantika2, Nova Lidia Sitorus2
1Faculty of Medicine, Universitas Indonesia, Depok 16424, Jawa Barat, Indonesia.
Children (Basel, Switzerland)
|October 26, 2024
概括
在发展中国家的儿童中,缺铁性贫血 (IDA) 和衰老有联系. 发育迟缓的儿童面临着明显更高的发展IDA的风险,这表明存在关心的协同作用关系.
科学领域:
- 全球健康 全球健康
- 儿童营养学 儿童营养学
- 流行病学 流行病学
背景情况:
- 缺铁性贫血 (IDA) 和衰老是全球主要的健康挑战,特别是在发展中国家.
- 之前的研究表明,IDA与儿童发育迟缓之间存在潜在联系.
- 了解这种关系对于公共卫生干预至关重要.
研究的目的:
- 系统地审查和分析IDA和儿科人口中衰老之间的关联.
- 综合现有关于发展中国家这种关系研究的证据.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Cochrane,EBSCO) 进行了全面的文献搜索.
- 包括15项研究在系统性审查中和4项在元分析中 (共计21,936名0-12岁的儿童).
- 使用NOS和EPHPP评估偏差风险;使用随机效应模型和GRADE评估进行元分析.
主要成果:
- 国际援助机构的患病率从3.6%到58.8%不等,而发育迟缓率从6.6%到44.5%.
- 九项研究发现了显著的关联;缩的儿童患IAD的风险高1.31-6.785倍.
- 患有IDA的儿童发育迟缓的几率比为2.27 (95% CI = 1.30-3.95);证据确定性低但重要.
结论:
- 在包括印度尼西亚在内的发展中国家,IDA的高患病率与儿童发育迟缓有关.
- 建议在儿科患者群体中IDA和衰老之间存在协同关系.
- 调查结果强调需要综合战略来解决这两种情况.
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