肺功能和心肺反应的性别差异30个月后COVID-19:一个巴西多中心研究
Cássia da Luz Goulart1,2,3, Guilherme Peixoto Tinoco Arêas1, Mauricio Milani3,4
1Physiological Science Department, Universidade Federal do Amazonas, Manaus 69067-005, Brazil.
International journal of environmental research and public health
|October 26, 2024
概括
在严重的COVID-19发生30个月后,与男性相比,女性在呼吸功能和心肺健康方面表现出持续的缺陷. 较长的住院时间进一步加剧了女性的这些长期影响.
科学领域:
- 肺部病理学 肺部病理学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 健康中的性别差异
背景情况:
- 严重的急性COVID-19可以导致长期的呼吸和心肺呼吸系统后果.
- 了解康复的性别差异和住院时间的影响对于有针对性的康复至关重要.
研究的目的:
- 为了研究呼吸功能,肌肉力量和努力限制的性别差异,在严重的COVID-19后的30个月.
- 评估住院时间对男性和女性幸存者的心肺呼吸能力的影响.
主要方法:
- 一个多中心的,横截面的观察性研究,涉及86名严重的COVID-19幸存者 (48名女性,38名男性).
- 评估肺功能和呼吸肌肉力量 (MIP,MEP).
- 心肺运动测试 (CPET) 用于评估心肺呼吸能力 (V ̇O2,O2脉冲,OUES).
主要成果:
- 妇女住院时间明显长,并显示出最大吸气压 (MIP) 降低.
- 雌性在CPET期间表现出较低的峰值氧气吸收 (V ̇O2),O2脉冲和氧气吸收效率斜率 (OUES).
- 妇女长时间住院 (>10天) 与更糟糕的O2脉冲,OUES和V ̇O2%的预测相关.
结论:
- 妇女在严重的COVID-19感染后30个月内表现出更显著和持久的心肺功能障碍.
- 较长的住院时间与较差的心肺呼吸系统结果有关,特别是在女性中,这突显了对性别特定的随访护理的需求.
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