马来西亚肥胖的遗传变异:一个全面的审查
Siti Sarah Hamzah1, Liyana Ahmad Zamri1, Norhashimah Abu Seman1
1Endocrine and Metabolic Unit, Nutrition, Metabolic & Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Selangor, Malaysia.
Genes
|October 26, 2024
概括
马来西亚人的遗传变异与肥胖风险有关. 需要进一步的研究,以了解人口层面的差异,并为这一公共卫生问题制定有针对性的干预措施.
科学领域:
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖在马来西亚是一个重大的公共卫生挑战,不仅仅是超重.
- 它涉及复杂的代谢和生理变化,需要全面的策略.
- 了解特定人口对肥胖的易感性对于有效管理至关重要.
研究的目的:
- 对马来西亚人口中关于肥胖风险的基因变异进行系统审查和编译.
- 突出这些遗传发现对马来西亚肥胖易感性的影响.
主要方法:
- 在Scopus,PubMed和ScienceDirect数据库中对2024年3月之前发表的文章进行了系统的文献搜索.
- 该审查遵循了PRISMA-ScR系统审查指南.
- 在最初确定的579篇文章中,有35篇被纳入最终分析.
主要成果:
- 在马来西亚的研究中,几种基因变异与肥胖有显著的关联.
- 值得注意的变种包括LEPR (K656N),LEP (G2548A - 仅在印度),ADIPOQ (rs17366568),UCP2 (45bp-I / D),ADRB3 (rs4994),MC3R (rs3827103),PPARγ (仅在pro12Ala-Malay),IL1RA (intron 2 VNTR),NFKB1 (rs28362491) 和FADS1 (仅在印度).
结论:
- 建议进一步进行密集的遗传研究,首先以基于人口的遗传数据为肥胖的概况,包括儿科人口.
- 社会文化和环境因素与遗传变异相互作用,强调需要量身定制的干预措施.
- 有针对性的战略对于减轻马来西亚肥胖的广泛影响至关重要.
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