在COVID-19患者的细菌和病毒共感染:病因学和临床影响
Ivelina Trifonova1, Iveta Madzharova1, Neli Korsun1
1National Laboratory "Influenza and ARD", Department of Virology, National Centre of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria.
在SARS-CoV-2患者中混合感染增加了严重程度和死亡风险. 多重检测对于识别共感染和指导及时,有针对性的治疗策略至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 微生物学 微生物学
背景情况:
- 混合感染,涉及多种病原体,可以加剧疾病的严重程度.
- 这项研究侧重于被诊断患有严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 的患者.
研究的目的:
- 调查SARS-CoV-2阳性患者病毒和细菌共感染的患病率和影响.
- 分析与这种人群中混合感染相关的临床结果.
主要方法:
- 使用多重PCR方法检测337个SARS-CoV-2阳性样本.
- 样本被选为与三种细菌和14种病毒病原体的共感染.
主要成果:
- 在8% (细菌),5.6% (病毒) 和1.4% (三重) 的患者中检测到并发感染.
- 血流感和RSV是常见的共致病原体. 5岁以下的儿童有更多的共同感染,但成年人经历了更严重的结果 (更高的CRP,更低的SpO2,更长的住院时间).
- 三重感染显著增加了死亡风险 (26%),ICU入院 (95%) 和致命结局 (p=0.005).
结论:
- 在SARS-CoV-2患者的共同感染多重检测是必不可少的.
- 快速识别使得有针对性的抗生素使用和改善患者管理.
更多相关视频
12:21A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Published on: September 28, 2022
09:02Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
相关概念视频
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Pneumonia II: Pathophysiology
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Pneumonia III: Complications and Assessment
Endocarditis II: Clinical features and Diagnostic Tests
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
