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肠道微生物群和血清生物标志物之间的关联在患有无氧性皮肤炎的儿童中

Irina G Kalashnikova¹, Alexandra I Nekrasova¹, Anna V Korobeynikova¹

¹Federal State Budgetary Institution "Centre for Strategic Planning and Management of Biomedical Health Risks" of the Federal Medical and Biological Agency, Pogodinskaya Str., 10/1, 119121 Moscow, Russia.

|October 26, 2024

概括

肠道细菌不平衡,或失生症,与增加的促炎性细胞因子有关,可能导致亚托皮性皮肤炎 (AD). 特定的细菌家族与关键的阿尔茨海默病生物标志物相关,揭示了肠道微生物组与阿尔茨海默病免疫反应之间的联系.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
遗传学遗传学是一种遗传学.

背景情况:

肠道微生物群显著影响免疫系统功能,并可以触发免疫介导反应,如阿托皮性皮炎 (AD).
细胞因子和化学因子是免疫反应的关键生物标志物,而改变的个人资料与包括阿托皮在内的疾病有关.
肠道细菌失衡扰乱AD免疫功能的确切机制尚不清楚.

研究的目的:

研究肠道细菌在调节相关的细胞因子通路中的作用.
为了确定特定的肠道细菌家族与免疫失调在患有亚托皮肤炎的儿童.

主要方法:

16S rRNA基因测序是在50名患有AD的儿童和50名健康对照者的便样本上进行的.
多重免疫光测定测量了血清中的41种细胞因子和化学因子,以评估免疫状态.
相关性分析 (斯皮尔曼) 用于将肠道微生物群组成与细胞因子水平联系起来.

主要成果:

在AD组中,肠道细菌家族和炎症性细胞因子之间发现了显著的相关性 (共191个,p ≤0.05).
在患有AD的儿童中,观察到促炎性细胞因子度的显著增加.
特定的细菌家族 (例如,Pasteurellaceae,Barnesiellaceae,Eubacteriaceae) 与已知的AD生物标志物 (例如IL-5,IL-13,TNF-α) 显示了相关性.

结论:

肠道失生症与改变的细胞因子概况有关,其特征是炎症性细胞因子升高.
这种肠道免疫系统失衡可能有助于在亚托皮性疾病中出现的Th2型免疫反应的发展.
这项研究强调了肠道微生物组变化与亚托皮性皮肤炎中关键免疫生物标志物之间的直接联系.

关键词:

16S rRNA 是一个16S rRNA.亚托邦性皮肤炎的发生.亚托巴亚托巴亚托巴亚亚多巴亚多巴亚多巴亚多巴亚多巴亚相关性分析的相关性分析.细胞因子细胞因子这种疾病叫做dysbiosis.我们的肠道微生物群.微生物组是一个微生物组.多重分析的多重分析.

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