较低的自由甲状腺素水平与患有2型糖尿病男性的糖尿病病有关:一项观测性横截面研究
Jianan Shang1, Yixuan Zheng2, Meng Zhang2
1Department of Ultrasound, The First Affiliated Hospital of Xi'an JiaoTong University, 277 West Yanta Road, Xi'an 710061, China.
Biomedicines
|October 26, 2024
概括
较低的甲状腺激素水平,包括自由甲状腺素 (FT4),与2型糖尿病患者患糖尿病病 (DKD) 的风险更高有关. 更高的FT4水平可以防止DKD.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 糖尿病病 (DKD) 是2型糖尿病 (T2DM) 的一个主要并发症.
- 甲状腺功能障碍越来越被认为是影响T2DM并发症的潜在因素.
研究的目的:
- 调查甲状腺功能与大批T2DM患者中的DKD存在之间的关联.
- 为了确定与DKD风险相关的特定甲状腺激素水平.
主要方法:
- 7516名T2DM患者的横截面研究,按DKD状态分类.
- 收集和比较临床,血糖,甲状腺功能和功能障碍的参数.
- 统计分析包括相关性和单变量/多变量逻辑回归.
主要成果:
- 与非DKD患者相比,DKD患者的三甲状腺素 (T3),甲状腺素 (T4),自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4) 水平明显较低.
- 较低的T3,T4,FT3和FT4水平与DKD风险和功能障碍标志物 (肌素,BUN,白蛋白尿) 有负相关性.
- 增加的FT4水平成为防治DKD的保护因素,特别是在男性中 (AUC=0.604).
结论:
- 甲状腺激素水平,特别是FT4,在T2DM患者中与DKD有显著的关联.
- 较低的甲状腺激素水平表明患有或发展甲状腺炎的风险增加.
- 维持适当的甲状腺激素水平,特别是FT4,可能有助于预防T2DM中的DKD.
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