年轻发病的结肠直肠神经内分泌新生瘤的人口特征和生存率
Deepak Vadehra1, Sahithi Sonti1, Beas Siromoni2
1Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Biomedicines
|October 26, 2024
概括
年轻发作的结直肠神经内分泌瘤 (YONEN) 显示出比腺癌 (YOADC) 更好的生存率. 对YONEN的种族差异进行进一步的研究对于有针对性的干预至关重要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 胃肠病学 胃肠病学
背景情况:
- 年轻发性结直肠癌 (YOCRC) 的发病率不断上升.
- 关于年轻发作的结直肠神经内分泌瘤 (YONEN) 的有限数据.
研究的目的:
- 调查YONEN的人口统计特征.
- 分析YONEN的生存趋势.
- 将YONEN与幼发性结直肠腺癌 (YOADC) 进行比较.
主要方法:
- 对SEER数据库进行了回顾性分析 (2000-2019年).
- 使用考克斯比例模型评估的生存结果.
- 使用威尔科克森等级和奇平方测试分析的人口差异.
主要成果:
- YONEN占年轻发作的结直肠癌的8%.
- 与YOADC相比,YONEN患者的黑人患者比例较高,白人患者比例较低.
- 在直肠中发生的YONEN更频繁 (79%) 与结肠中的腺癌 (57%).
- 与YOADC患者相比,YONEN患者的生存率更高.
- 西班牙裔YONEN患者的整体存活率比白人YONEN患者要好 (HR 0.67).
结论:
- 与YOADC相比,YONEN表现出不同的人口和生存概况.
- 在YONEN内部存在显著的种族差异.
- 进一步调查种族差异对于政策和干预发展至关重要.
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