在患有结性脊柱炎的患者心血管风险
Aleksandra Klisic1,2, Jelena Kotur-Stevuljevic3, Osman Cure4
1Faculty of Medicine, University of Montenegro, 81000 Podgorica, Montenegro.
Journal of clinical medicine
|October 26, 2024
概括
结性脊柱炎患者表现出与腰围,LDL胆固醇和疾病活性相关的亚临床动脉样硬化. 年龄和葡萄糖代谢因素显著预测了心动脉内膜介质厚度的增加,突出了多因素的心血管风险.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 生物标志物 生物标志物
背景情况:
- 结性脊柱炎 (AS) 是一种慢性炎症疾病,与心血管疾病 (CVD) 风险增加有关.
- 亚临床动脉样硬化是心血管疾病的前体,通过复杂的多因素途径与AS有关.
- 了解这些联系对于管理AS患者的心血管健康至关重要.
研究的目的:
- 调查心动脉内膜介质厚度 (cIMT) - - 亚临床动脉样硬化的一个标志物 - - 与AS患者心脏代谢生物标志物之间的联系.
- 在患有结椎炎的个体中确定cIMT的关键预测因子.
- 探索疾病活动和代谢因素在AS中动脉样硬化发展中的作用.
主要方法:
- 对96名结性脊柱炎患者的前性研究.
- 用超声波测量动脉内膜介质厚度 (cIMT).
- 多重线性回归和主要成分分析 (PCA) 用于识别预测因素和生物标志物集群.
主要成果:
- 腰围,LDL胆固醇和BASDAI得分与cIMT独立相关.
- PCA确定了四个生物标志物集群:血液学-脂质,炎症性-原血栓性,LDL-c-维生素和年龄-葡萄糖代谢.
- 年龄葡萄糖代谢因子是增加cIMT的显著独立预测因子 (p < 0.001).
结论:
- 疾病活动 (BASDAI),腰围和LDL胆固醇独立地与AS的亚临床动脉样硬化有关.
- 心脏代谢风险因素,特别是年龄和葡萄糖代谢,在AS患者的动脉样硬化发展中起着重要作用.
- 异质性心脏代谢因素可能会导致结性脊髓炎中亚临床动脉样硬化背后的各种病理生理过程.
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