维生素D受体在COVID-19阴性,感染和接种疫苗的妇女怀孕期间的相互作用
Constantin Condac1,2, Ludmila Lozneanu3, Daniela Roxana Matasariu4,5
1Department of Anesthesia and Intensive Care, "Cuza Vodă" Hospital, 700038 Iasi, Romania.
Journal of clinical medicine
|October 26, 2024
概括
孕妇的COVID-19感染与较低的胎盘维生素D受体水平有关. 这种缺陷可能会导致胎儿的不良后果,如降低出生体重.
科学领域:
- 产科和妇科 产科和妇科
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 胎盘,特别是热囊细胞,是怀孕期间维生素D合成的关键部位.
- 维生素D在胎儿的发育和生长中起着至关重要的作用.
- 孕妇COVID-19感染与胎儿负面结果有关,但根本机制尚未完全理解.
研究的目的:
- 为了研究COVID-19感染,胎盘结构和功能,以及 trofhoblast细胞中维生素D受体 (VDR) 水平之间的关系.
- 通过改变VDR表达来探索一种潜在的机制,将母体COVID-19与胎儿不良结果联系起来.
主要方法:
- 分析了来自三个组的170个产后胎盘样本的队列:COVID-19阳性未接种疫苗的妇女,COVID-19阴性接种疫苗的妇女和COVID-19阴性未接种疫苗的妇女.
- 免疫组织化学 (IHC) 用于量化维生素D受体 (VDR) 在胎盘组织中的表达.
- 评估了胎儿的直接结果,包括出生体重和Apgar分数.
主要成果:
- 与接种疫苗和未接种疫苗的对照组相比,COVID-19阳性妇女在出生时表现出较低的妊娠年龄和较低的出生体重.
- 在COVID-19阳性母亲中观察到胎盘VDR水平显著降低.
- 在较低的VDR水平和阴性胎儿结果之间发现了相关性.
结论:
- 胎盘中的维生素D受体 (VDR) 是胎儿和胎盘生长的组成部分.
- 在COVID-19阳性怀孕中,胎盘VDR水平降低可能是导致胎儿不良结果的因素.
- 需要进一步的研究,以阐明维生素D在病毒感染期间怀孕期间代谢的精确作用.
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