长期高流鼻疗法在患有不同严重程度的支气管切除症的患者:回顾性队列研究
Cecilia Calabrese1, Santi Nolasco2,3, Anna Annunziata4
1Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Azienda Ospedaliera di Rilievo Nazionale dei Colli, Monaldi Hospital, 80131 Naples, Italy.
Journal of clinical medicine
|October 26, 2024
概括
高流量鼻腔疗法 (HFNT) 显著减少非囊性纤维化支气管支气管病 (NCFB) 患者的年度恶化. 随着疾病的严重程度和每日HFNT使用,有效性会增加,改善呼吸不良和减少细菌殖民.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 肺部病理学 肺部病理学
- 医疗器械 医疗器械
背景情况:
- 高流量鼻腔疗法 (HFNT) 在降低COPD和非囊性纤维化支气管支气管病 (NCFB) 患者的恶化方面表现有前途.
- 以前的证据表明,HFNT有利于NCFB患者,但不同严重程度的有效性需要进一步调查.
研究的目的:
- 为了比较家庭HFNT在轻度/中度和重度NCFB患者的年度恶化率上的12个月有效性.
- 评估接受HFNT的NCFB患者的呼吸障碍,肺功能和唾液培养等二次结局.
主要方法:
- 一项86名患者的研究招募了成年NCFB患者,他们之前在优化治疗中出现过严重恶化.
- 患者接受了12个月的家庭HFNT,在基线和随访时评估了恶化,mMRC得分,肺功能和唾液培养.
- 患者被分为轻度/中度 (支气管切开症严重程度指数[BSI] < 9) 和严重 (BSI ≥ 9) 的两组.
主要成果:
- 轻度/中度和严重的NCFB组都显示了每年恶化率的显著降低 (p < 0.0001).
- 两组之间的显著差异表明,在重症组每年出现的恶化病例减少了1次 (p = 0.0209).
- HFNT使mMRC得分提高了-2分 (p < 0.0001),并使P. aeruginosa*的殖民率从34.9%降低到27.9%.
结论:
- 长期的家庭HFNT有效地减少了NCFB患者每年的恶化.
- HFNT的有效性与疾病严重程度 (BSI) 和每日设备使用有积极的相关性.
- 在NCFB患者中,HFNT还可以改善呼吸障碍并降低细菌负载.
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