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胎儿瘤:诊断和管理方面的进步

May Abiad¹, Nikan Zargarzadeh¹, Ali Javinani¹

¹Fetal Care and Surgery Center (FCSC), Division of Fetal Medicine and Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Journal of clinical medicine

|October 26, 2024

概括

胎儿瘤是来自多能细胞的罕见瘤. 通过产前成像和多学科管理的早期诊断,包括EXIT程序,改善了受影响的新生儿的结果.

科学领域:

生殖医学生殖医学
儿科瘤学儿科瘤学
胎儿外科手术胎儿外科

背景情况:

胎儿瘤,来自多能细胞的罕见瘤,严重程度各不相同.
诊断依赖于产前超声波和MRI进行风险评估.
管理是复杂的,特别是水滴或呼吸道阻塞等并发症.

研究的目的:

审查胎儿瘤的诊断方法.
探索当前的管理策略和结果.
突出提高新生儿存活率和降低发病率方面的进展.

主要方法:

对包括超声波和MRI在内的诊断方式的审查.
分析管理策略,包括多学科方法和EXIT程序.
评估结局和胎儿治疗的最新进展.

主要成果:

产前成像对于诊断和风险分层至关重要.
多学科的护理和干预,如EXIT程序,对于严重的病例至关重要.
对高风险瘤来说,个性化监测是必不可少的.

结论:

胎儿治疗的进步提高了瘤新生儿的存活率.
早期检测和量身定制的管理是减少发病率的关键.
需要继续进行研究,以进一步优化胎儿瘤的结果.

关键词:

从子宫外进行产后治疗 (EXIT).胎儿外科手术胎儿手术胎儿子宫瘤胎儿子宫瘤这是一种神圣的瘤 (sacrococcygeal teratoma).

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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...