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粘弹性静血检测作为肝移植中高凝血的诊断工具:叙述性审查
Khaled Ahmed Yassen1, Dur I Shahwar1, Aqeel Qasem Alrasasi2
1Anaesthesia Unit, Surgery Department, College of Medicine, King Faisal University, P.O. Box 400, AlAhsa 31982, Saudi Arabia.
Journal of clinical medicine
|October 26, 2024
概括
粘弹性血液静止测试 (VETs) 在肝移植期间检测高凝血性方面表现有前途,优于标准凝血测试. 需要进行进一步的研究,为这种复杂的外科手术程序制定VET指导的治疗指南.
科学领域:
- 移植手术 移植手术
- 血液学 血液学 血液学
- 麻醉学 麻醉学
背景情况:
- 肝移植涉及复杂的凝血动态,存在高凝血和出血的风险.
- 末期肝病患者表现出微妙的血静平衡,容易转向血栓形成或出血.
- 外科手术期间的高凝血可导致严重的并发症,如肝移植中的血栓栓塞.
研究的目的:
- 评估粘弹性静血弹性试验 (VETs) 在肝移植期间诊断高凝血性的有效性.
- 为了比较VETs与标准凝血测试 (SCT) 的灵敏度,以检测早期高凝血.
- 突出需要基于证据的指导方针,以VET为指导,管理高凝血性.
主要方法:
- 审查最近关于肝移植中的凝血功能障碍的研究.
- 在VET (ROTEM,TEG) 和SCT (质血红素时间,aPTT) 之间对诊断能力的比较.
- 分析VET参数,包括凝血时间,凝血强度和纤维解.
主要成果:
- 标准凝血试验 (SCT) 诊断早期高凝血能力的能力有限.
- 粘弹性静血弹性试验 (VETs) 在识别患有血栓形成风险的患者方面表现出更高的灵敏度.
- 职业教育和培训提供了对凝块形成,强度和纤维素分解的全面评估.
结论:
- 与SCTs相比,VET提供了一个更敏感的方法来诊断肝移植接受者的高凝血性.
- 根据职业教育和培训的结果,有必要制定基于证据的预防和治疗指南.
- 优化职业教育和培训的利用可以改善患者的治疗结果,并减少肝移植后的血栓性并发症.
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