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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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电离辐射剂量不同影响宿主-微生物关系随着时间的推移.

Nabarun Chakraborty1, Allison Hoke1, Ross Campbell1,2

  • 1Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

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|October 26, 2024
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概括
此摘要是机器生成的。

全身辐射 (TBI) 破坏了小鼠和肠道细菌之间的共生关系,改变了免疫健康和生物能量. 这项研究揭示了辐射后微生物组成和功能的关键变化,为TBI症状干预提供了洞察力.

关键词:
16S rRNA 基因测序的基因测序下降结肠内容 下降结肠内容便代谢物的便代谢物便中的微生物群功能性的元基因组.主体微生物组协会整个身体的辐射辐射.

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科学领域:

  • 微生物学 微生物学
  • 免疫学 免疫学 免疫学
  • 系统生物学 系统生物学

背景情况:

  • 肠道微生物群影响宿主免疫力和能量代谢.
  • 暴露于辐射会引起炎症并改变能量需求.
  • 主体-微生物关系是双向的,对辐射等环境压力因素敏感.

研究的目的:

  • 研究全身辐射 (TBI) 对小鼠肠道微生物组成和功能的影响.
  • 确定受不同剂量的TBI影响的特定细菌种类和生物功能.
  • 阐明TBI对宿主-微生物共生关系的后果.

主要方法:

  • 小鼠被暴露在9.5Gy和11Gy的TBI中.
  • 下降结肠含量 (DCCs) 在TBI后的1,3,9天被收集.
  • 在DCC上进行了16S rRNA基因测序和元基因组分析.

主要成果:

  • 随着时间的推移,TBI显著改变了肠道细菌的多样性和丰富性.
  • 在Gy TBI后的第9天和第11天观察到微生物特征的显著差异,Firmicutes和Deferribacteres的增加.
  • 功能网络分析揭示了活性细菌脂质代谢和生物能量合成,与抑制的代谢物通路形成鲜明对比.

结论:

  • 致命的辐射破坏了小鼠及其肠道微生物群之间的共生关系.
  • 创伤后微生物组成和功能的变化会影响宿主生物能和免疫力.
  • 这些发现为制定有针对性的干预措施以减轻TBI引起的症状提供了基础.