托克索卡拉·卡尼斯 (Toxocara canis) 和类动物对狗肠道微生物群多样性和组成的影响
Na Wang1, Soben Sieng1,2, Ping Chen1
1Laboratory of Tropical Veterinary Medicine and Vector Biology, Hainan Province Key Laboratory of One Health, School of Life and Health Sciences, Collaborative Innovation Center of One Health, Hainan University, Haikou 570228, China.
Microorganisms
|October 26, 2024
概括
这项研究表明,肠道圆虫Toxcara canis感染减少了狗的肠道微生物群多样性. 包括Drontal Plus® Tasty在内的虫治疗方法恢复了这种多样性,改变了关键的细菌类和属.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 寄生虫学的寄生虫学
背景情况:
- 托克索卡拉·卡尼斯 (Toxocara canis) 感染带来了显著的动物感染风险.
- 德伦特普拉斯 (Drontal Plus® Tasty) 是一种常见的治疗T. canis在狗,含有Febantel,Praziquantel和Pyrantel Pamoate (PP).
- 关于这些杀虫剂对狗肠道微生物群的影响的研究有限.
研究的目的:
- 调查Drontal Plus® Tasty及其活性成分对感染T. canis.的狗肠道微生物群的影响.
- 分析虫治疗后微生物多样性和组成的变化.
主要方法:
- 通过无菌导管从狗身上采集肠道内容样本.
- 用于微生物分析的16S rRNA高通量测序.
- 生物信息分析以评估α和β多样性,以及分类构成.
主要成果:
- 感染T. canis导致肠道微生物群的丰富性和多样性下降.
- 虫治疗增加了微生物的多样性和丰富性.
- 德伦特普拉斯 (Drontal Plus® Tasty) 显著增加了巴西洛塔的比例;费班特尔,普拉齐特尔或PP改变了巴西洛塔和巴克特罗伊多塔.
- 虫药物降低了Clostridium_sensu_stricto和增加了Segatella的丰富性,而Drontal Plus® Tasty没有影响Segatella.
结论:
- 虫治疗显著改变了狗肠道微生物群的丰富性和多样性.
- 特定的杀虫剂对细菌类和属组成有着不同的影响.
- 了解这些微生物转变对于管理犬类寄生虫感染和整体肠道健康至关重要.
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