一个分析的看法,使用流西林为门诊患者的肠道抗菌药物治疗
Tam Nguyen1, Isabel Spriet2, Charlotte Quintens2
1Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven, Herestraat 49, O&N2, PB 923, 3000 Leuven, Belgium.
Microorganisms
|October 26, 2024
概括
在33°C的便携式弹性体输液 (PEIP) 中,如果初始pH值在5.9以上,则FLU在24小时内保持稳定. 高于33°C的温度和较低的初始pH值显著降低了克洛西林的稳定性.
科学领域:
- 制药科学 制药科学
- 药物的稳定性 药物的稳定性
- 抗菌疗法是一种抗菌疗法.
背景情况:
- 尽管稳定性较低,但非缓冲性流西林 (FLU) 溶液在临床上更受青.
- 便携式弹性体输液 (PEIP) 用于门诊亲肠道抗菌疗法 (OPAT).
研究的目的:
- 评估使用PEIPs的OPAT在33°C正常盐水中的50mg/mlFLU溶液24小时的稳定性.
- 为了研究温度和初始pH对非缓冲溶液中FLU稳定性的影响.
主要方法:
- 在PEIP中的溶液在33°C保存24小时,每4小时检查体积,pH和FLU度.
- 在制冷,室温,37°C和组合条件下进行了额外的稳定性测试.
- 评估了初始pH对FLU稳定性和沉物形成的影响.
主要成果:
- 在33°C下24小时后,FLU保持超过92%的稳定,但在37°C下降至<85%.
- 在冷藏 (>99%) 和室温 (>95%) 条件下稳定性很高.
- 较低的初始pH (<5.9) 降低了稳定性,在33°C下降到<90%,沉物形成在pH值5.3左右.
结论:
- 在PEIP中的FLU适合在高达33°C的温度下24小时使用.
- 保持初始pH值至少为5.9对于确保FLU稳定性至关重要.
- 温度和初始pH值是影响非缓冲溶液中的克洛西林稳定性的关键因素.
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