口腔微生物转位基因在胃肠道癌症:从元基因组分析的见解
Linqi Wang1, Qinyu Wang1, Yan Zhou1
1State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.
Microorganisms
|October 26, 2024
概括
口腔微生物可以迁移到肠道,可能导致结肠直肠癌 (CRC) 和炎症性肠病 (IBD). 这项研究提供了与这些胃肠道疾病相关的口腔转位基因 (OTGs) 的遗传证据.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 胃肠病学 胃肠病学
背景情况:
- 口腔微生物群落影响口腔健康.
- 这些社区可能会转移到肠道,可能导致胃肠道疾病.
- 对口腔病原体转移到肠道的遗传证据有限.
研究的目的:
- 确定与结直肠癌 (CRC) 和炎症性肠病 (IBD) 相关的口腔转位基因 (OTGs).
- 研究特定的口腔病原体,如Leclercia adecarboxylata在胃肠道恶性瘤中的作用.
- 为口腔病原体向肠道迁移提供基因水平的证据.
主要方法:
- 识别了超过55,000个口腔转位基因 (OTGs).
- 分析基因功能,特别是信号转导和细胞壁生物合成.
- 评估CRC患者的肠道微生物群组成,重点关注*Leclercia adecarboxylata*的丰富性.
主要成果:
- 超过55,000个OTG与CRC和IBD相关,在两种条件下都保留了功能.
- *Leclercia adecarboxylata* 在CRC患者的肠道微生物群中显示出明显更高的丰度.
- 来自L.adecarboxylata的OTG在15个代谢途径中得到了丰富,包括氨基酸和辅助因子代谢.
结论:
- 这项研究提供了第一个口腔病原体转移到肠道的遗传证据.
- 口腔病原体及其相关基因在胃肠道癌症的发展中起作用.
- 这些发现为CRC和IBD的病原体提供了新的见解.
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