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体重指数调解了宏观营养素亚型与表型年龄加速之间的关联.
Kai He1, Tong Xu1, Xingxu Song1
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
Nutrients
|October 26, 2024
概括
饮食质量影响衰老. 高质量的碳水化合物,总蛋白质和植物蛋白质摄入量与表型衰老缓慢相关. 用更健康的选择取代质量差的宏观营养素可能会减少生物衰老.
科学领域:
- 营养科学 营养科学
- 老年学是指老年学的学科.
- 生物标志物 生物标志物
背景情况:
- 饮食和衰老是相关的,但特定的宏观营养素亚型与表型衰老加速的关联是不充分研究的.
- 身体质量指数 (BMI) 在饮食-表型衰老关系中的调解作用仍然不清楚.
研究的目的:
- 调查宏观营养素亚型与表型衰老加速 (PhenoAgeAccel) 之间的关联.
- 确定BMI在多大程度上调解这些关联.
主要方法:
- 对6911名国家健康和营养检查调查参与者的分析 (≥20岁).
- 计算每日宏观营养素摄入量,并按分类四分位数分类.
- 使用九个化学生物标志物进行PhenoAgeAccel计算.
- 多变量线性回归,同热量替代和调解分析.
主要成果:
- 高质量的碳水化合物,总蛋白质和植物蛋白质摄入量与PhenoAgeAccel有负面关联.
- 和脂肪酸 (SFAs) 的摄入量与PhenoAgeAccel. 积极相关.
- 将低质量的宏观营养素替换为高质量的营养素,使PhenoAgeAccel减少了约25%.
- 在PhenoAgeAccel上,BMI部分调解了高质量的碳水化合物 (19.76%) 和总脂肪 (30.78%) 的影响.
结论:
- 宏观营养素亚型与PhenoAgeAccel有不同的关系.
- 体重指数 (BMI) 部分调解了宏观营养素质量与衰老之间的关系.
- 饮食转向更高质量的宏观营养素可能会减缓生物衰老.
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