肠道屏障损伤,保存和修复:最新情况
Ayah Matar1, John A Damianos1, Kara J Jencks1
1Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Nutrients
|October 26, 2024
概括
饮食营养素和肠道微生物显著影响肠道屏障功能. 特定的营养素和益生菌可以增强肠道健康,提供对胃肠道疾病的保护作用.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 肠道屏障对于防止病原体进入和维持肠道平衡至关重要.
- 改变肠道透性与各种胃肠道疾病有关.
- 饮食和肠道微生物组在调节屏障功能方面发挥着重要作用.
研究的目的:
- 审查有关肠道屏障功能和透性的文献.
- 检查饮食成分和微生物群对肠道屏障健康的影响.
- 探索恢复肠道屏障功能的策略.
主要方法:
- 使用关键词的文献综述:肠道屏障,透性,微生物组,表观基因组学,饮食,刺激性肠道综合征,炎症性肠道疾病,益生菌.
- 对饮食影响,微生物相互作用和表观基因组修改研究的分析.
主要成果:
- 饮食中的脂肪增加了肠道的透性,而纤维,谷氨酸,,维生素D,多,乳化剂和酸盐降低了它.
- 微生物群与屏障相互作用,通过细菌抗原影响炎症,并产生像短链脂肪酸这样的抗炎化合物.
- 表观基因组的修改会影响屏障功能,特别是连接蛋白和炎症.
结论:
- 肠道透性对于保护胃肠道疾病至关重要.
- 营养素和微生物群衍生产品可以保护,治愈和修复肠道屏障.
- 饮食干预和益生菌提供了恢复正常屏障功能和促进抗炎作用的机会.
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