人类母乳外基因组:影响因素,它们的可能健康结果,以及饮食学的未来方向
Elif Çelik1, Özge Cemali2, Teslime Özge Şahin3
1Department of Nutrition and Dietetics, Faculty of Health Sciences, Süleyman Demirel University, Isparta 32260, Türkiye.
Nutrients
|October 26, 2024
概括
人类母乳含有外生体,它们是转移影响婴儿健康和发育的生物活性分子的囊泡. 需要进一步的研究才能充分理解它们的功能和对婴儿福祉的影响.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 儿科 儿科 儿科
背景情况:
- 人类母乳是一种复杂的液体,对婴儿的免疫和代谢发育至关重要.
- 它含有营养素,生物活性分子和外体,对新生儿健康至关重要.
- 外体越来越多地被认为是母乳的重要组成部分.
研究的目的:
- 审查影响母乳外体细胞的因素.
- 检查牛奶外体对婴儿健康的影响.
- 探索未来的研究方向对外体在饮食学中的外体.
主要方法:
- 现有科学文献的叙事审查.
- 专注于人类母乳中的外体,它们的组成部分和健康影响.
- 分析了对外体转移和婴儿潜在表观遗传影响的研究.
主要成果:
- 外体是细胞外囊泡 (20-200 nm),可以携带DNA,RNA,蛋白质和脂质.
- 人母乳外体组件可能会转移到婴儿身上,可能导致表观遗传修饰.
- 这些变化可以影响婴儿组织中的基因表达和细胞调节.
结论:
- 母乳中的外体与婴儿免疫功能,氧化应激和细胞循环调节有关.
- 它们对婴儿的短期和长期健康都有作用.
- 需要更多的研究来阐明母乳外基因组的全部功能和对健康的影响.
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