严重运动和智力障碍患者肠道微生物组组成和身体特征之间的关联:从微生物多样性的角度来看
Suzumi Kageyama1,2, Rikako Inoue3,4, Koji Hosomi4,5
1Graduate School of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, Japan.
Nutrients
|October 26, 2024
概括
患有严重运动和智力障碍 (SMID) 的患者有类似婴儿的肠道微生物组,其低多样性与身体严重程度和改变的胆酸有关. 这表明SMID患者的肠道环境未成熟.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 人类的衰老 人类的衰老
背景情况:
- 肠道微生物组的组成随着宿主年龄的增加而发生显著变化.
- 研究了严重运动和智力障碍 (SMID) 患者的肠道微生物群多样性.
- 研究了肠道微生物组,身体特征和多样性水平之间的关联.
研究的目的:
- 分析SMID患者的肠道微生物群多样性.
- 为了将微生物组组成与身体严重程度和肠道环境相关联.
- 为了确定高多样性 (HD) 和低多样性 (LD) 群体之间的肠道微生物组和代谢物的差异.
主要方法:
- 研究了14名受试者,根据身体状况,排便,血液检查,微生物组概况和便代谢物,将他们分为HD (8) 和LD (6) 组.
- 收集有关身体和排便状态的数据.
- 分析了肠道微生物群和便代谢物,包括胆酸 (BAs).
主要成果:
- 在LD组的微生物组显示延迟成熟,类似于新生儿.
- LD组的脱氧胆酸 (二次胆酸) 显著降低,这表明初级转化为二次BA转化受损.
- 腰部疾病患者表现出更大的身体严重性,躺在床上,只接受肠道配方,经常有松散的便.
结论:
- 在LD组的肠道微生物组和胆酸概况与健康个体和HD组不同.
- 这表明,在肠道微生物群多样性较低的SMID患者中,肠道环境可能不成熟.
- 改变肠道微生物组的组成和功能与SMID的身体严重程度有关.
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