定期的运动训练诱导了更多的变化,从血液和微生物群组成的肠道葡萄糖吸收在瘦的比较重的个人在单胞胎双胞胎不一致的BMI的肠道葡萄糖的组成
Martin S Lietzén1, Maria Angela Guzzardi2, Ronja Ojala1
1Turku PET Centre, University of Turku, 20521 Turku, Finland.
Nutrients
|October 26, 2024
概括
运动可以改善肠道葡萄糖吸收 (GU) 和肠道微生物群,但效果因肥胖状况而异. 瘦个体在运动后显示出结肠GU和微生物群多样性的更大改善,独立于遗传学.
科学领域:
- 代谢生理学 代谢生理学
- 肠道微生物组研究研究
- 运动科学 运动科学
背景情况:
- 肥胖会对肠道葡萄糖吸收 (GU) 和肠道微生物群组成产生负面影响.
- 众所周知,定期运动可以改善胰岛素刺激的GU,并调节肠道微生物群.
- 遗传学对肠道GU和肠道微生物群的运动诱导变化的影响仍然在很大程度上未被探索.
研究的目的:
- 研究遗传学对运动对肠道葡萄糖吸收 (GU) 和肠道微生物群的影响的作用.
- 为了比较具有不同肥胖程度的基因相似个体之间的运动诱导的GU和微生物群的变化.
主要方法:
- 进行了为期六个月的运动干预,对12对单胞胎双胞胎进行了干预,这些双胞胎对BMI不一致.
- 用[18F]FDG-PET成像评估胰岛素刺激的小肠和结肠GU.
- 从便样本中分析了肠道微生物组成,使用16s rRNA测序.
主要成果:
- 与较瘦的双胞胎相比,更重的双胞胎表现出较低的基线小肠和结肠GU.
- 运动干预导致双胞胎对之间GU的不同反应,更瘦的双胞胎显示结肠GU的增加.
- 虽然这两组都显示出微生物组的改变,但结肠GU和微生物群多样性的显著变化主要观察到更瘦的双胞胎.
结论:
- 肥胖会影响胰岛素刺激的肠道GU,不论其基因背景如何.
- 运动引起了结肠GU和肠道微生物群组成的显著改善,特别是在更瘦的个体中.
- 这些发现突出了肥胖,运动和肠道微生物群之间的相互作用,对反应变异性有潜在的遗传影响.
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