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益生菌补充对皮质醇水平的影响:系统性审查和元分析

Manav Jain¹, Aishwarya Anand², Nisha Sharma³

¹Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT 84108, USA.

|October 26, 2024

概括

益生菌补充剂可能会降低皮质醇水平,特别是在不服用其他药物的健康个体和使用单一菌株时. 需要进一步的研究来澄清这些影响在特定人群.

科学领域:

微生物学和免疫学
胃肠病学胃肠病学
内分泌学在内分泌学.

背景情况:

关于益生菌对不同人群中皮质醇水平的影响存在相互矛盾的结果.
之前的分析受限于研究数量,并没有根据健康状况,地区或治疗特征探索变化.
需要综合当前关于益生菌如何影响皮质醇的证据,并确定调节这种关系的因素.

研究的目的:

系统地审查和元分析随机对照试验 (RCT),调查益生菌给药对皮质醇水平的影响.
根据健康状况,同时服用的药物,益生菌菌株类型,治疗持续时间和地理区域,探索益生菌对皮质醇影响的潜在变化.

主要方法:

在多个数据库 (PubMed,Embase,Scopus等) 中进行全面的搜索. 是针对相关的RCT进行的.
随机效应元分析被用来合成来自46个涉及3516名参与者的RCT的数据.
使用Cochrane RoB 2工具评估偏见,使用GRADE评估证据确定性.

主要成果:

总的来说,与对照组相比,益生菌补充剂显著降低了皮质醇水平 (SMD: -0.45,低确定性证据).
在没有同时服用药物的子组 (SMD: -0.30),单一益生菌菌株 (SMD: -0.33),健康人群 (SMD: -0.30) 和亚洲地区的研究 (SMD: -0.83) 中观察到皮质醇降低.
在大多数分析中都发现了很高的异质性 (I2 > 88%).

结论:

目前的低确定性证据表明,益生菌可能会降低皮质醇水平.
这些影响在特定的子组中显得更加明显,包括健康人群,不服用其他药物的人群,以及使用单株益生菌时.
需要更有针对性的研究来阐明精确的机制,并确定影响益生菌对皮质醇调节有效性的关键变量.

关键词:

这是一种 bifidobacterium 细菌.皮质醇是一种皮质醇.我们的肠道微生物群.乳酸菌种 (lactobacillus) 是一种植物.益生菌是一种益生菌.

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