使用天然聚合物,以喷雾干燥的方式封装欧原醇
Aitor Caballero-Román1, Anna Nardi-Ricart1, Roser Vila2
1Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona (UB), Avinguda Joan XXIII, 27-31, 08028 Barcelona, Spain.
Pharmaceutics
|October 26, 2024
概括
喷雾干燥成功地使用天然聚合物封装了欧原醇,创造了稳定的微囊. 这种方法提高了eugenol的稳定性,eugenol是一种因其抗菌和抗氧化特性而广泛使用的化合物.
科学领域:
- 食品科学 食品科学 食品科学
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 烯醇是子油的关键成分,具有宝贵的消毒剂,麻醉剂和抗氧化剂特性.
- 它来自Syzygium aromaticum (L.) 的天然来源使其成为一个受欢迎的化合物.
- 尤根醇易受光和空气的降解,因此需要保护性配方策略.
研究的目的:
- 为了优化喷雾干燥过程,用于封装eugenol.
- 评估各种配方参数对封装效率和产品回收的影响.
- 开发含有欧原醇的稳定,可生物降解的聚合物微囊.
主要方法:
- 采用因数设计方法来研究五个变量:入口温度,吸尘器和流量,均化方法和eugenol:聚合物比率.
- 使用了天然的涂层材料,包括马尔托德克斯特林,阿拉伯和大豆莱西丁.
- 测量的主要结果包括工艺产量,出口温度,封装效率和颗粒大小 (d{0.9}).
主要成果:
- 最优的配方使用的是1:2的欧原醇与聚合物比率和Ultra-Turrax®同质化.
- 最好的配方 (DF22) 实现了欧原醇封装效率在47.37%至65.69%之间.
- 产品回收率超过57.20%,微囊大小从22.40微米到55.60微米不等.
结论:
- 喷雾干燥过程已成功优化,以实现欧原醇封装.
- 有效地制备了含有欧原醇的可生物降解和稳定的聚合物微囊.
- 这种方法提供了一个可行的解决方案,以保护eugenol在配方中的降解.
相关概念视频
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Overview
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
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