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Updated: Jun 9, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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通过3D-QSAR和分子对接研究开发新型ROCK抑制剂:多向药物设计框架

Milan Beljkas1, Milos Petkovic2, Ana Vuletic3

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.

Pharmaceutics
|October 26, 2024
PubMed
概括

新的候选药物C-19和C-22显示出作为癌症治疗的多位抑制剂的前景. 这些化合物向与Rho相关的卷状卷状含蛋白激酶 (ROCK) 和基因素脱乙酶 (HDAC),可能改善转移性瘤的疗效.

关键词:
3D-QSAR 是一个3D-QSAR.罗关联蛋白激酶 (rho-associated protein kinases) 是一种与蛋白质相关的酶.抗瘤药剂是一种抗瘤药剂.乳腺癌 乳腺癌 乳腺癌分子建模分子建模多个目标导向的带.胰腺管道腺癌瘤有理性的药物设计.

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