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相关概念视频

Bioreactor Controls-I01:28

Bioreactor Controls-I

Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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从基于德克斯的冷凝中控制释放的实验和建模研究.

Carolina Lauriola1, Laura Di Muzio2, Patrizia Paolicelli2

  • 1Dipartimento di Ingegneria Chimica, Materiali e Ambiente, Sapienza Univerisità di Roma, 00184 Rome, Italy.

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|October 26, 2024
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概括

基于德克斯的冷凝提供了可控的药物释放. 在冷凝形成之前加载药物会导致更慢的非Fickian释放,受冷凝度的影响,非常适合持续的分娩.

关键词:
有控制释放的释放.结冷缩度的使用方法基于德克斯的冷凝.非Fickian释放中的非Fickian释放运输建模 运输建模

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科学领域:

  • 生物材料科学 生物材料科学
  • 聚合物化学 聚合物化学
  • 药物输送系统 药物输送系统

背景情况:

  • 冰凝是高度多孔的聚合物网络,在低温下形成.
  • 基于德克斯的材料具有生物相容性,并且广泛用于生物医学应用.
  • 控制药物释放系统对于治疗疗效和患者的遵守至关重要.

研究的目的:

  • 为了研究由五种不同的基于德克斯的冷凝中控制释放的维生素B12.
  • 为了比较两种不同的药物加载程序产生的药物释放概况.
  • 阐明控制药物释放的机制,特别是非Fickian行为.

主要方法:

  • 合成了五种不同成分的基于德克斯的冷凝 (DEX40PEG360MA,DEX40PEG500MA).
  • 在交叉链接之前,通过形成后输注和形成前合并进行药物加载.
  • 使用维生素B12作为模型药物的体外药物释放研究.
  • 使用Fickian和非Fickian模型分析释放动力学,包括用于冷的两步释放过程.

主要成果:

  • 根据加载方法观察到两种不同的药物释放特征.
  • 快速的Fickian释放发生在药物被注入预先形成的,冷干燥的冷凝中时.
  • 缓慢的,高度非Fickian释放,以长时间的延迟时间为特征,由在冷凝形成之前加载药物引起.
  • 这种非Fickian行为归因于冷集中现象,并通过两步过程准确地建模.

结论:

  • 基于德克斯的冷凝是控制药物输送的有效矩阵.
  • 药物加载策略显著影响释放动力学.
  • 化缩现象在实现这些冷凝中持续的非Fickian药物释放方面发挥着关键作用.