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Updated: Jun 9, 2025

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预测无形固体分散的释放机制:热力学建模和分子模拟的组合

Stefanie Walter1, Paulo G M Mileo2, Mohammad Atif Faiz Afzal3

  • 1AbbVie Deutschland GmbH & Co. KG, Small Molecule CMC Development, Knollstraße, 67061 Ludwigshafen am Rhein, Germany.

Pharmaceutics
|October 26, 2024
PubMed
概括

调查无形固体分散 (ASD) 显示,药物负载显著影响释放机制和释放损失 (LoR). 结合热力学建模和分子模拟,为优化ASD配方和减少实验测试提供了强大的计算框架.

关键词:
DPD DPD 的意思是警察局.在PC-SAFT中使用.无形固体分散的无形固体分散粗粒度建模粗粒度建模消散性粒子动态的粒子动力学液态-液态相隔离方法 液态相隔离方法阶段行为 阶段行为释放 释放 释放 释放 释放

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